Products > Resins for Peptide Synthesis > Trityl Chloride Resin
Trityl Chloride Resin
Catalog # |
Cross Linker (DVB) |
Particle Size
(mesh) |
Loading
(mmol/g) |
Price (US $) |
10 g |
25 g |
100 g |
500g |
152001
152002
152003
152004 |
1%
1%
1%
1% |
100-200
100-200
200-400
200-400 |
0.4-1.0
1.0-1.6
0.4-1.0
1.0-1.6 |
116.00
121.00
116.00
121.00 |
201.00
210.00
201.00
210.00 |
353.00
383.00
353.00
383.00 |
1,080.00 1,153.00 1,080.00 1,153.00 |
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The trityl chloride resin is a highly acid-labile support for the immobilization of alcohols [1-4], sugars [5], amines [6-12], hydroxylamines [13], imidazoles [14], carboxylic acids [15], and thiols [16,17]. Cleavage is generally achieved using 1-5% TFA in DCM containing 5% TIS. This resin can also be used in peptide synthesis [15,16]. Cyclopentadienes have been immobilized to this resin using nickelocene as a source of cyclopentadiene [18].
References
[1] C. C. Leznoff , Acc. Chem. Res., 1978, 11, 327.
[2] C. Chen, et al., J. Am. Chem. Soc., 1994, 116, 2661.
[3] Z. Li & A. Ganesan, Syn. Lett., 1998, 405.
[4] K. Barlos, et al., Liebigs Ann. Chem., 1998, 1079.
[5] F. Peri, et al., Tetrahedron Lett., 2000, 41, 8587.
[6] M. Schuster, et al., Angew. Chem. Int. Ed. Engl., 1996, 35, 1979.
[7] P. Garibay, et al., Tetrahedron Lett, 1998, 39, 2207.
[8] Y. Guan, et al., J. Comb. Chem., 2000, 2, 297.
[9] S. Manku, et al., J. Org. Chem., 2001, 66, 874.
[10] D. Jönsson, et al., Tetrahedron Lett., 2001, 42, 6953.
[11] K. Stromgaard, et al., J. Med. Chem., 2000, 43, 4526.
[12] F. Wang, et al., Org. Lett. 2000, 2, 1581
[13] U. Bauer, et al., Tetrahedron Lett., 1997, 38, 7233.
[14] D. P. Matthews, et al., J. Comb. Chem., 2000, 2, 19.
[15] K. Barlos, et al., Tetrahedron Lett., 1989, 30, 3943.
[16] S. Mourtas, et al., Tetrahedron Lett. 2003, 44, 179
[17] S. Mourtas, et al., Tetrahedron Lett. 2002, 43, 3419
[18] N. E. Leadbeater, Tetrahedron Lett. 2002, 43, 691
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