Products > Resins for Peptide Synthesis > Rink Amide Resin




Rink Amide Resin

Catalog #

Cross Linker (DVB)

Particle Size
(mesh)

Loading
(mmol/g)

Price (US $)

25 g

100 g

500 g

151801 151802 151803 151804

1%
1%
1%
1%

100-200
100-200
200-400
200-400

0.3-0.6
0.6-1.0
0.3-0.6
0.6-1.0

250.00
267.00
250.00
267.00

750.00
800.00
750.00
800.00

2,950.00
3,150.00
2,950.00
3,150.00



Rink resin is an acid labile resin widely used to prepare amides [1], amide derivatives, and other organic molecules [2-5]. For example, Rink's amide linker can be employed directly as an alkylated diversity scaffold to yield N-alkylated amides upon cleavage from the solid support. Although the rink technology is limited to the preparation of amides and carboxylic acids, the utility of Rink-chloride can allow the attachment of various nucleophiles with a wide range of functional groups to the resin, such as amines, alcohols and thiols [2].In addition, the method of Rink resin trifluoroacetate can be used to prepare phenols [3] and purines [4,5].

Refenences

[1] H. Rink Tetrahedron Lett., 1987, 28,3787.
[2] S. L. Mellor & W. C. Chan J. Chem. Soc., Chem. Commun., 1997, 2005.
[3] R. S. Garigipati Tetrahedron Lett., 1997, 38,6807.
[4] W. K. D. Brill, et al. Synlett., 2001, 7,1097.
[5] W. K. D. Brill & C. Riva-Toniolo Tetrahedron Lett., 2001, 42,6515.