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> Rink Amide-MBHA Resin
Rink Amide-MBHA Resin
|
Catalog # |
Cross Linker (DVB) |
Particle Size
(mesh) |
Loading
(mmol/g) |
Price (US $) |
10 g |
25 g |
100 g |
500g |
151809
151810 |
1%
1% |
100-200
200-400 |
0.3-1.0
0.3-1.0 |
224.00
224.00 |
420.00
420.00 |
1,103.00
1,103.00 |
3,328.00
3,328.00 |
Rink Amide-MBHA resin is less acid sensitive than Rink Amide resin because the benzhydrylamine linker is joined to the support through an electron-withdrawing acetamido spacer [1]. Normally the product is detached from the resin using 95%TFA in DCM plus scavengers as required by the composition of the substrate [1,2]. However, it is also useful for preparing peptides. Boussard, Cyrille et al. has recently reported that. Syntheses of tri- and tetra- and pentapeptides were performed via a solid phase synthesis methodology using a Rink Amide MBHA resin [3].
References
[1] Bernatowicz, M. S.; Daniels, S. B.; Köster, H. Tetrahedron Lett. 1989,30,4645.
[2] M. Lebl, et al., J. Comb. Chem., 1999, 1, 474
[3] Boussard, Cyrille et al. European Journal of Medicinal Chemistry,37(11),2002, pp.883-890. |
